This is a promising start to a new series. The world is Lovecraftian with a focus on rationality to the point where fanciful drawings in the margins of a paper will earn severe punishment, likely in the form of a public burning with steam. Aoife's greatest fear is that on her 16th birthday she will become insane, just as her brother did on his 16th birthday and their mother before him (though not on her 16th birthday). The culprit is a necrovirus which along with stealing a person's sanity can also turn them into hideous creatures.
It's a bleak but very interesting world and I loved the twist at the end.